Description
This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. “In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields.” – Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine Part I – ELEMENTS OF REGENERATIVE MEDICINE 1. Definitions 2. History of Regenerative Medicine 3. Basic Principles and Current Approach for Soft Tissue Regeneration 4. Sophisticated Biocomposite Scaffolds from Renewable Biomaterials for Bone Tissue Engineering Part II – RESEARCH CONCEPTS 5. Mechanotransduction in wound healing and scar formation 6. Stromal Cell-Derived Factor1 (SDF-1) Signaling and Tissue Homeostasis 7. Stem Cell Differentiation Directed by Material and Mechanical Cues 8. Bacteriophages: a New (Yet Old) Weapon against Infections 9. Bacteriophages as Biocontrol Agents of Biofilm Infections Associated with Abiotic Prosthetic Devices 10. Extracellular vesicles derived from Mesenchymal Stem/Stromal Cells: Current Approaches to Enhance Their Release and Therapeutic Potential 11. Anti-Biofilm Activity of Viruses, Bacteria, Fungi and Lichens: Mechanisms and Impact on Clinical Practice Part III – EMERGING TECHNOLOGIES 12. Bionic Reconstruction: The New Frontier 13. Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators 14. Biomimetics: A New Abstraction for Bone Implant Design 15. The Role of Microbiota in Skin Regeneration 16. Erythropoietin: An Innovative Therapeutic Approach in Thermal Trauma 17. Targeting C-Reactive Protein in Inflammatory Disease 18. Stem Cell Therapies for Tissue Regeneration and Wound Healing: Strategies to Enhance Therapeutic Effectiveness 19. Iron Chelators & HIF-1a: A new Frontier for Skin Rejuvenation Part IV – TRANSLATIONAL ASPECTS 20. How to Overcome the Valley of Death from Basic Science to Clinical Trials 21. Moving Your Results from Bench to Bedside: Protecting Scientific Findings 22. The Regulatory Landscape of Cell- and Tissue-Based Regenerative Medicine: Current Challenges and Emerging Issues 23. Translational Challenges in Soft Tissue Regeneration 24. Bone Tissue Engineering Challenges in Craniofacial Reconstructive Surgeries 25. Translational Challenges: Lymph Node Tissue Engineering 26. Implementing Tissue Engineering and Regenerative Medicine Solutions in Silicone Implants Part V – REGENERATIVE PLASTIC SURGERY 27. Microdeformational Wound Therapy 28. Clinical Treatment of Hypertrophic Scars 29. Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells 30. Reconstruction of Post-Traumatic Maxillary Ridges Using a Radial Forearm Free Flap and Allogeneic Tissue Engineered Bone Grafts 31. Postoperative Complications of Mandibular Fracture Management 32. Use of Porcine Urinary Bladder Matrix (UBM-ECM) in the Head and Neck Region 33. Advances in Facial Nerve Paralysis: Surgical Innovation, Tissue Engineering, and Emerging Technology 34. Management of Capsular Contracture: Non- Surgical and Surgical Options 35. Soft Tissue Reconstruction of the Lower Limb
