Description
This volume provides detailed technical protocols on current biosensors and imaging technologies and Chapters focus on optical, electrochemical, Quartz crystal microbalance (QCM) biosensors and on medical imaging technologies such as tomography, MRI, and NMR. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Biomedical Engineering Technologies, Volume 1 provides technical details in descriptions of major technologies by experts in the field. Part I: Optical 1. A Compact Surface Plasmon Resonance Biosensor for Sensitive Detection of Exosomal Proteins for Cancer’ Diagn Yun Wu, Xie Zeng, and Qiaoqiang Gan 2. Electrochemistry Coupling Localized Surface Plasmon Resonance for Biochemical Detection Zetao Chen, Yanli Lu, Qingqing Zhang, Diming Zhang, Shuang Li, and Qingjun Liu 3. Preparation of surface plasmon resonance aptasensor for human activated protein C sensing Semra Akgnll, Seda Koyun, Handan Yavuz, Arzum Erdem, and Adil Denizli 4. Large-scale nanogrooved photonic crystals for label-free biosensing by guided-mode resonance Miquel Avella-Oliver, Gabriel Sancho-Fornes, Rosa Puchades, and ngel Maquieira 5. Plasmonic Nanoparticle Conjugation for Nucleic Acid Biosensing Amogha Tadimety, Yichen Zhang, John H. Molinski, Timothy J. Palinski, Gregory J. Tsongalis, and John X.J. Zhang 6. Ultrasensitive Label-Free Nucleic-Acid Biosensors Based on Bimodal Waveguide Interferometers Cesar S. Huertas, and Laura M. Lechuga 7. Azimuthal Beam Scanning Microscope Design and Implementation for Axial Localization with Scanning Angle Interference Microscopy Marshall Colville, Sangwoo Park, Avtar Singh, Matthew Paszek, and Warren Zipfel 8. Computational Optics for Point-of-Care Breast Cancer ProfilingJouha Min, Matthew Allen, Cesar M. Castro, Hakho Lee, Ralph Weissleder, and Hyungsoon Im 9. DNA genotyping based on isothermal amplification and colorimetric detection by consumer electronics devices, Luis Antonio Tortajada-Genaro 10. Evaluation of tumor development using hemoglobin saturation profile on rodent dorsal window chamber Miguel R. Ossandon, Brian S. Sorg, Dhananjay S. Phatak, and Konstantinos Kalpakis 11. Automated multidimensional nanoscale chromatography for ultra-sensitive targeted mass spectrometry Paolo Cifani, and Alex Kentsis 12. Clinical Translation of Stimulated Raman Histology Cordelia Orillac, Todd Hollon, and Daniel A. Orringer 13. Ex vivo and in vitro methods for detection of bioactive staphylococcal enterotoxins Reuven Rasooly, Paula Do, and Bradley Hernlem 14. An Ultracompact Real-time Fluorescence Loop-mediated Isothermal Amplification (LAMP) Analyzer, Gihoon Choi, and Weihua Guan 15. Digital Quantification of Human Viral RNA and DNA using a Self-Digitization Chip Jiasi Wang, Jason E. Kreutz, and Daniel T. Chiu 16. Sample-to-Answer Microfluidic Nucleic Acid Testing (NAT) (file #on Lab-on-a-Disc for Malaria Detection at Point-of-Need Gihoon Choi, and Weihua Guan 17. Charge sensitive optical detection for measurement of small molecule binding kinetics Shaopeng Wang, Guangzhong Ma, Runli Liang, and Nongjian Tao 18. Mobile Elisa With A Transparent Incubator Arsenii Zhdanov, Cassidy Chen, Crystal Schmitt, Tyler Tripp, Chase Miller, and Anna Pyayt 19. Smartphone Enabled Point-of-Care Detection of Serum Biomarkers Jacob T. Heggestad, David S. Kinnamon, Jason Liu, Daniel Y. Joh, Cassio M. Fontes, Qingshan Wei, Aydogan Ozcan, Angus M. Hucknall, and Ashutosh Chilkoti 20. Micromachined Optical Fiber Sensors for Biomedical Applications Chen Zhu, Rex E. Gerald II, and Jie Huang PART II: Electrochemical and Piezoelectric 21. Optical and electrochemical aptasensors for sensitive detection of aflatoxin B1 and aflatoxin M1 in blood serum, grape juice and milk samples Mohammad Ramezani, Seyed Hamid Jalaliana, Seyed Mohammad Taghdisi, Khalil Abnous, and Mona Alibolandi 22. DNA Generated Electric Current Biosensor for Epidermal Growth Factor Receptor 2 (HER2) Analysis, Xiaoqing Li, Congcong Shen, Minghui Yang, and Avraham Rasooly 23. Agar-Integrated Three-Dimensional Microelectrodes for On-Chip Impedimetric Monitoring of Bacterial Viability Derrick Butler, and Aida Ebrahimi 24. Quantitative and selective DNA detection with portable personal glucose meter using loop-based DNA competitive hybridization strategy Fei Liu, Bin Wang, Yanke Shan, Wenjie Kang, Jiahao Li, Xin Wang, and Jing Liu 25. Electrochemical aptamer-based sensors: a platform approach to high frequency molecular monitoring in situ in the living body Philippe Dauphin-Ducharme Kyle L. Ploense, Netzahualcyotl Arroyo-Currs, Tod E. Kippin, and Kevin W. Plaxco 26. Smartphone-based Electrochemical System for Biosensors and Biodetection Daizong Ji, Sze Shin Low, Diming Zhang, Lei Liu, Yanli Lu, and Qingjun Liu 27. Preparation of notch-4 receptor containing quartz crystal microbalance biosensor for MDA MB 231 cancer cell detection Monireh Bakhshpour, Ayse Kevser Piskin, Handan Yavuz, and Adil Denizli 28. The study of the skin cells viscoelastic changes using QCM-D measurements Anna Sobiepanek, and Tomasz Kobiela Part III: Monitoring and Imaging 29. Hyperpolarized micro-NMR platform for sensitive analysis of in vitro metabolic flux in living cells Sangmoo Jeong, and Kayvan R. Keshari 30. Mixed Modeling Frameworks for Analyzing Whole-Brain Network Data Sean L. Simpson 31. Rapid In Vivo Quantification of Creatine Kinase Activity by Phosphorous-31 Magnetic Resonance Spectroscopic Fingerprinting (31P-MRSF) Charlie Wang, Kihwan Kim, and Xin Yu 32. Nanoparticle assisted nuclear relaxation-based detection of oligonucleotides Rebecca N. Silva, and Peng Zhang 33. Imaging Biomarker Development for Lower Back Pain using Machine Learning Bilwaj Gaonkar, Kirstin Cook, Bryan Yoo, Banafsheh Salehi, and Luke Macyszyn 34. Acoustic Angiography: Superharmonic Contrast-Enhanced Ultrasound Imaging for Non-Invasive Visualization of Microvasculature Isabel G. Newsome, and Paul A. Dayton 35. Patch Clamp Technology for Focused Ultrasonic (FUS) (file #Neuromodulation Eun Sok Kim 36. Wireless Wearable Ultrasound Sensor to Characterize Respiratory Behavior Ang Chen, Rachel Diane Rhoades, Andrew Joshua Halton, Jayden Charles Booth, Xinhao Shi, Xiangli Bu, Ning Wu, and Junseok Chae 37. Forming large effective ultrasound arrays using the swept synthetic aperture technique Nick Bottenus 38. Quantitative bioluminescence tomography for in vivo volumetric-guided radiotherapy Zijian Deng, Xiangkun Xu, Hamid Dehghani, Daniel M). Sforza, Iulian Iordachita, Michael Lim, John W. Wong, and Ken Kang-Hsin Wang 39. Evaluation of pulmonary structure and function in patients with cystic fibrosis from electrical impedance tomography data Jennifer L. Mueller 40. In-Vivo Quantitative Whole-Body Perfusion Imaging Using Radiolabeled Copper(II) (file #bis(thiosemicarbazone) (file #Complexes and Positron Emission Tomography (PET) Mark A. Green, Carla J. Mathias, Nathaniel J. Smith, Monica Cheng, and Gary D. Hutchins 41. Biodegradable AuNP-based plasmonic nanogels as contrast agents for computed tomography and photoacoustics Mathilde Bouch, and David P. Cormode 42. Cationic Contrast Agents for Computed Tomography of Cartilage for Early Diagnosis of Osteoarthritis Chenzhen Zhang, Ambika G. Bajpayee, and Tengfei He 43. Economical production of radiopharmaceuticals for preclinical imaging using microdroplet radiochemistry Jia Wang, and R. Michael van Dam 44. Preparation of radiolabeled antibodies for nuclear medicine applications in immuno-oncology Junnian Wei, David Y. Oh, and Michael J. Evans 45. A Wireless Fully-Passive Acquisition of Biopotentials Shiyi Liu, Xueling Meng, Jianwei Zhang, and Junseok Chae 46 . Fabrication of Skin-Mountable Flexible Sensor Patch for Monitoring of Swallowing Function Heun Park, Min Ku Kim, Georgia A). Malandraki, and Chi Hwan Lee 47. The Intelligent Phenotypic Plasticity Platform (IP3) (file #for Precision Medicine-based Injury Prevention in Sport Adam W. Kiefer, Cortney N. Armitano-Lago, Anoop Sathyan, Ryan MacPherson, Kelly Cohen, and Paula L. Silva
